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Tumorogénesis y proteína mdm2
(Sociedad Médica de Santiago, 2000)
Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer
(Springer, 2014-11-01)
Actinic cheilitis exhibits a potential of malignant transformation in 10-20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell ...
Mdm2 promotes Cdc25C protein degradation and delays cell cycle progression through the G2/M phase
(Nature Publishing Group, 2017-06)
Upon different types of stress, the gene encoding the mitosis-promoting phosphatase Cdc25C is transcriptionally repressed by p53, contributing to p53’s enforcement of a G2 cell cycle arrest. In addition, Cdc25C protein ...
Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus
(2013-01-30)
Objective: The objective of this study was to compare the expression of proteins p53, MDM2, and SUMO-1 in oral lichen planus (OLP) lesions, epithelial dysplasia, and squamous cell carcinoma. Materials and Methods: The ...
Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus
(2013-01-30)
Objective: The objective of this study was to compare the expression of proteins p53, MDM2, and SUMO-1 in oral lichen planus (OLP) lesions, epithelial dysplasia, and squamous cell carcinoma. Materials and Methods: The ...
Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws
(Pergamon-elsevier Science LtdOxfordInglaterra, 2001)
Proliferating cell nuclear antigen (PCNA), p53 and MDM2 expression in Hodgkin's disease
(Associacao Paulista Medicina, 2007-03-01)
CONTEXT and OBJECTIVE: Tumor cells in Hodgkin's disease (HD) express cell proliferation markers that are evaluated according to the oncogenes involved or the expression of their proteins. Correlations between the protein ...
Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs
(Elsevier Ireland, 2014-08)
The human homologue of mouse double minute 2 (MDM2) is overexpressed in tumors and contributes to tumorigenesis through inhibition of p53 activity. We investigated the effect of the anti-estrogen fulvestrant on MDM2 ...